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World Parkinson’s Day: Horizon project AI-PROGNOSIS using AI to improve Parkinson’s diagnosis and care

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Parkinson’s disease affects more than one million people in the EU and this number is expected to double by 2030, primarily due to an aging population.

To mark World Parkinson’s Day, HaDEA interviewed Prof. Leontios Hadjileontiadis, coordinator of AI-PROGNOSIS, a Horizon Europe research and innovation project aiming to advance Parkinson’s disease diagnosis and care through novel predictive models combined with digital biomarkers from everyday devices, such as smartphones and smartwatches.

Prof. Hadjileontiadis, tell us more about AI-PROGNOSIS.

AI-PROGNOSIS is focused on improving Parkinson’s disease diagnosis and care through predictive models driven by artificial intelligence (AI) and digital biomarkers from everyday devices. The project aims to enhance early detection, predict disease progression and optimise treatment responses, thereby personalising patient care. By leveraging data from smartphones and smartwatches, AI-PROGNOSIS offers valuable insights into individual risk and treatment efficacy, ultimately improving the quality of life for those with Parkinson’s disease.

What can you tell us about your project’s use of AI? Have you encountered any challenges in integrating your solutions in broader healthcare systems?

The lack of interoperability with legacy electronic health record systems has made integrating AI tools into existing clinical workflows difficult. Many healthcare institutions still use outdated systems not designed to support advanced AI technologies. Building trust and acceptance among healthcare professionals and patients has also been a challenge. There is often scepticism about the accuracy and reliability of AI models and concerns about the potential for AI to replace human roles in healthcare. Overcoming these concerns requires continuous education and demonstration of the AI tools’ benefits and reliability.

Navigating the complex regulatory landscape for AI in healthcare has added to the challenges. Ensuring that AI tools meet all legal and ethical standards is essential for their adoption and use. Additionally, accessing existing datasets has been difficult due to data ownership and sharing restrictions, which limit the amount of data available for training AI models. Recruiting patients for studies and trials has also been challenging, as it requires significant time and resources to ensure a diverse and representative sample.

These challenges underscore the importance of a collaborative and adaptive approach in developing and implementing AI solutions in healthcare, ensuring they are both effective and widely accepted.

Could you elaborate on this collaborative and adaptive approach?

AI-PROGNOSIS has adopted a comprehensive and inclusive approach to identify the needs of key stakeholders, including patients, healthcare professionals, and researchers. The project emphasises continuous engagement and collaboration with these groups to ensure the tools developed are user-friendly and meet their needs.

This includes:

  • Multidisciplinary workshops: AI-PROGNOSIS organises workshops bringing together experts from various fields to discuss and refine project goals and methodologies;
  • Patient involvement: Patients are actively involved in the design and testing phases, providing valuable feedback on usability and functionality;
  • Input from health professionals: Regular consultations with doctors and therapists help tailor the AI tools to clinical workflows and practical needs;
  • Input from the external advisory board: Expert guidance on the ethical implementation, strategic integration, industry perspectives and impactful application of AI-PROGNOSIS output in Parkinson’s disease research and care.

This collaborative and iterative approach ensures that AI-PROGNOSIS remains aligned with the real-world needs of its stakeholders, enhancing its impact on Parkinson’s diagnosis and care.

Having consulted with numerous stakeholders, can you give us an example of how this feedback has been used?

For example, in one of the focus groups that we ran, healthcare professionals shared how challenging it was to be informed about their patients’ changing symptoms across the course of the illness. This insight helped us develop the mAI-Insights application, which allows healthcare professionals to receive frequent updates and alerts about their patients’ symptoms.*

With the project running until 2027, how important is the EU’s financial support throughout the project life cycle?

The support of EU funding is crucial for our project. It provides financial resources for extensive research, developing advanced AI models, and integrating digital biomarkers from everyday devices. EU funding under the Horizon Europe programme also facilitates collaboration among multidisciplinary European teams, ensuring that the project benefits from diverse expertise and perspectives. Additionally, this support helps navigate regulatory challenges and promotes the adoption of innovative solutions in healthcare systems. Without EU funding, achieving the project’s ambitious goals and significantly impacting Parkinson’s diagnosis and care would be much more challenging.

*The project also features two other applications: mAI-Health for persons with suspected Parkinson’s to track their personalised risk and mAI-CARE for persons with diganosed Parkinson’s to track symptoms, disease progression and treatment efficacy.

Background

Horizon Europe is the research and innovation programme of the EU for the period 2021-2027. The aims of Cluster 1 ‘Health’ include improving and protecting the health and well-being of citizens of all ages by generating new knowledge, developing innovative solutions and integrating where relevant a gender perspective to prevent, diagnose, monitor, treat and cure diseases. Horizon 2020 (H2020) was the EU’s multiannual funding programme between 2014 and 2020.

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ESMA consults on rules for external reviewers of European Green Bonds

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The European Securities and Markets Authority (ESMA), the EU’s financial markets regulator and supervisor, has today published its Consultation Paper on the remaining Regulatory Technical Standards (RTS) for external reviewers under the European Green Bonds Regulation.

The RTS relate to the following aspects of the external reviewer regime:

  • appropriateness, adequacy and effectiveness of systems, resources and procedures;
  • authority, resources, expertise and access to relevant information of the compliance function;
  • soundness of administrative and accounting procedures, internal control mechanisms and effectiveness of information systems controls;
  • quality and reliability of sources of the information used for external reviews;
  • information, form and content of applications for recognition; and
  • notification of material changes in the information provided at registration.

ESMA considers that these technical standards will enhance the robustness and transparency of external reviews of European Green Bonds and in turn boost investors’ confidence that their capital is genuinely driving the green transition.

The first consultation on RTS for external reviewers under the European Green Bonds Regulation took place in 2024.

Next steps

ESMA will consider the feedback received to the consultation by 30 May 2025 and expects to publish a Final Report and submit the draft RTS to the European Commission for adoption by 21 December 2025 at the latest. The technical standards will also be subject to non-objection by the European Parliament and Council.

ESMA particularly encourages external reviewers operating during the transitional regime or intending to apply to become an ESMA-registered external reviewer of European Green Bonds to participate in the consultation.

Further information:

Dan Nacu-Manole

Communications Officer
press@esma.europa.eu

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Paris at a Crossroads: Anne Hidalgo’s Failure vs. the Renewal Brought by Rachida Dati

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Paris, the City of Light, now seems overshadowed by a contested management. While outgoing mayor Anne Hidalgo faces mounting criticism for her economic, social, and environmental record, Rachida Dati, Minister of Culture and an emerging figure in Parisian right-wing politics, represents an alternative, pragmatic vision focused on the future. A look at the reasons for disapproval and the promises of renewal.

The Clear Shortcomings of Hidalgo’s Term

  1. A Catastrophic Financial Management The debt of the City of Paris now reaches “€9 billion,” a historic record that burdens future generations. This situation stems from questionable choices, such as financing “urban farms” that are unproductive, symbols of ideological ecology rather than concrete results. Worse still, the property tax jumped from “13.5% to 20.5% in 2022,” penalizing small property owners and the middle class, without solving the deficit.
  2. Cleanliness and Quality of Life: A Systemic Failure According to opinion surveys, “84% of Parisians consider their city dirty” and 73% are dissatisfied with the maintenance of public spaces. A damning observation regularly pointed out by the opposition, notably Rachida Dati, who denounces the “chaotic management” of municipal services. Despite public consultations, such as the one on parking fees (94% abstention), Hidalgo persists in a technocratic approach, disconnected from local realities.
  3. Judicial Scandals and Political Discredit Anne Hidalgo’s term has been tainted by investigations into illegal conflicts of interest and embezzlement, particularly regarding a trip to Tahiti in 2023. The raids at City Hall in March 2024 and the €30,000 in excessive phone expenses have reinforced the image of an opaque municipal team. Her crushing failure in the 2022 presidential election (1.75% of the vote), the worst score for the Socialist Party, reflects the national—and Parisian—rejection of her agenda.
  4. A Climate of Sterile Confrontation Rather than defending her achievements, Hidalgo has resorted to personal attacks against Rachida Dati, even publicly accusing her of using civil servants for her legal activities—a claim that led to a “defamation lawsuit” in 2025. This strategy poorly masks the lack of strong arguments.

Rachida Dati: The Experience and Vision to Revive Paris

  1. A Woman of Action with Proven Competence Former Minister of Justice and current Minister of Culture, Rachida Dati combines “experience in public policy” with a deep understanding of local issues. Her tenure as Minister of Culture is marked by concrete initiatives, such as her proposal to have the Eiffel Tower classified as a historical monument, aimed at strengthening its protection—although Hidalgo blocked this proposal due to clientelism.
  2. A Vision for an Attractive and Supportive Capital In contrast to Hidalgo, Dati advocates for a “pragmatic and inclusive” vision:

Affordable Housing: Priority given to renovating social housing and combating slumlords.

Cleanliness and Safety: Reinforcement of cleaning teams and partnerships with districts for decentralized management.

Economic Attractiveness: Support for local businesses and simplification of procedures for companies.

  1. Transparent and Collaborative Management During the Covid-19 crisis, Dati demonstrated her efficiency by organizing “drive-through testing and mask distribution” in her district, criticizing the inaction of the central city administration. Her approach contrasts with Hidalgo’s failures, who was accused of “neglecting the preparation for deconfinement.”
  2. Culture and Heritage: Restoring Paris’ Luster In addition to supporting the Eiffel Tower, Dati promotes a “renovation plan for historic monuments” and supports popular cultural events. She aims to make Paris a “festive capital,” combining tradition and modernity, far from costly and ineffective experiments.

Turning the Page on Ideology, Writing the One of Pragmatism

Anne Hidalgo’s record is clear: historic debt, a dirty city, public distrust, and political clientelism. In contrast, Rachida Dati represents a “democratic renewal” based on expertise, transparency, and listening to Parisians. While the 2024 Olympic Games have showcased Paris’ potential under calm management, the time has come to hand over the keys to the capital to a leader who can balance ambition and realism. Paris deserves more than Hidalgo’s rear-guard battles: it deserves the fresh air brought by Rachida Dati.

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Moldovan President Maia Sandu: Moldovan priests must respect the laws of the country they serve

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Moldovan President Maia Sandu commented on March 31 on information that fugitive oligarch Ilan Shor, under the guidance of Moscow, is using Moldovan priests to advance his interests in the country’s parliamentary elections. The head of state condemned the priests who contacted Shor, stressing that breaking the law leads to punishment, Moldovan media outlet NewsMaker.md reports. “They serve in this country and must respect both the country and its laws,” Sandu added.

On the air of the program “La 360 de grade on Radio Moldova,” Sandu was asked how situations in which priests get involved in political games can be prevented. In response, she stressed that priests are citizens of Moldova and must respect its laws. “Priests should know that they are citizens of this country and have the same obligations as any other citizen. If they follow orders coming from outside, it means they are breaking the law and will be punished like everyone else. They should understand that they serve in this country and must respect the country and its laws,” said Sandu.

When asked whether such priests could be held accountable, she replied that all those who break the law should be punished. “Using foreign money for election purposes is a violation of the law,” added Maya Sandu.

We recall that in September of last year, information appeared that dozens of priests from the Metropolitanate of Moldova had made a pilgrimage to Moscow, and upon their return, they received Promsvyazbank cards, to which they were promised to transfer salaries and financial assistance to the church. The travel expenses were borne by Ilan Shor. A media investigation indicated that the priests were thus bribed before the presidential elections in Moldova and the upcoming referendum.

In January of this year, the head of the General Inspectorate of Police, Viorel Cherneucanu, reported that Shor – under the direction of Moscow – had organized and paid for a trip of Moldovan priests to Serbia under the pretext of pilgrimage.

Initially, the Metropolitanate of Moldova condemned the actions of the priests and promised to monitor their participation in propaganda and political actions. However, it was later stated that the trip of the Moldovan priests to Moscow had been organized and paid for by the Russian Orthodox Church.

Subsequently, President Sandu called on Moldovan priests not to interfere in politics and not to participate in actions aimed at destabilizing the situation in the country.

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