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Cells, Immune cells, Septic shock and metastases, finding the culprits

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How can cells and Immune cells of the human body respond quickly to physical and chemical changes in their environment?

Although genetic mutations can cause changes to the properties of a cell, non-genetic mechanisms can drive rapid adaptation, in a process broadly termed cell plasticity. Cell plasticity is involved in fundamental biological processes in health and disease. For example, tumour cells can shift from a highly proliferative state to a more invasive state, and thus promote cancer metastasis. On the other hand, during inflammation, immune cells can transform into cells that execute an inflammatory response and promote tissue repair. Uncontrolled inflammation that gets out of hand can lead tissue damage and ultimately septic shock.

A group at Institut Curie in Paris now found a new culprit of these processes on a molecular level; work that was published recently in the scientific journal Nature.

The researchers found that cells responsible for metastasis formation or immune cells implicated in inflammation and sceptic shock have increased amounts of copper, which is responsible for changes in cell plasticity. Interestingly, copper is taken up into cells via a protein called CD44 and hyaluronic acid, also known to be an ingredient in many beauty products. There was already proof of metal uptake by CD44 in cancer cells by the research team, published previously in the journal Nature Chemistry. CD44 is a protein that has been widely studied for decades and found in many cell types, including cells of the immune system, cancer cells, cells involved in wound healing, progenitor cells of red blood cells and many more. The scientists showed that copper taken up by CD44 accumulates in mitochondria of the cells, which are organelles responsible for energy production.

Illustration: model of the study. Image credit: Institut Curie

Further police work to investigate the fundamental processes have led to the findings that copper controls metabolism in these mitochondria, i.e. has direct effects on the energy production of the cell. This in turn changes levels of molecules called metabolites, which influence how genes are read in the cell. In particular levels of NAD(H) were affected, which are one of the most known and most important metabolites known in human cells. In short, these changes have an effect what the cell can do and look like and affect its function.

Furthermore, the scientists developed a new small drug-like molecule, based on the anti-diabetes drug metformin, which can block these processes by binding and inactivating this copper. This then influences the energy production of the cell and ultimately its function. In the context of immune cells, the researchers could thus achieve less aggressive immune cells and dampen inflammation in mouse models. This new drug prototype could rescue mice of septic shock.

The researchers Raphael Rodriguez, Stephanie Solier and Sebastian Muller. Image credit: Beloncle Frank/Institut Curie.

But that was not all. The study also showed that these fundamental processes underlying inflammation are also found in cancer, more specifically in molecular events that can trigger metastasis formation! Thus, this approach could potentially be adopted to fight metastasis. Since more than 11 million people die of septic shock in the world per year and 90% of cancer deaths are due to metastases, there is now big hope that this can be developed into new medications, which could help many patients on a global scale.

Overall, This study now shows great promise, both on a molecular fundamental research level and potential clinical applications. It also poses the question of how much copper is good for us?

Source: Institut Curie

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EU treading Dangerous Waters: The Perils of Psychedelics in Therapeutic Use

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The European Commission is getting ready to review citizens’ proposals and one controversial idea on the table is the ‘PsychedeliCare’ initiative that supports the exploration and implementation of psychedelic treatments for mental wellbeing issues. Advocates of this initiative highlight the advantages of using psychedelics in addressing mental health concerns; however it’s crucial to carefully assess the consequences of making these substances mainstream for therapeutic use, it already happened with way too many “pharma products” and end up being dangerous street drugs, as this is what they actually were from the beginning.

The Illusory Promise of Psychedelics

Supporters of this “therapies” frequently promote these substances as amazing remedies for profound mental health challenges like depression and anxiety disorders such as PTSD are regularly highlighted by them in support of their claims. However, these early research findings are willfully misinterpreted and exaggerated. The “positive outcomes” observed in limited research studies do not automatically translate to safety and effectiveness across wider and more varied demographic groups, often the contrary. Throughout history the fascination with a quick fix for mental health issues has often resulted in disappointment and harm, if not death.

A Lack of Comprehensive Understanding

The insufficient scientific knowledge about psychedelics raises concerns within the community as the intricate workings of the human brain remain a mystery when influenced by these substances. There are risks such as psychological distress and worsening of preexisting mental health conditions that make it unthinkable to integrate psychedelics into mainstream therapy practices at all. It is crucial to acknowledge the variations in individual experiences and biological compositions to prevent unintended harm rather than aiding in treatment efforts.

Regulatory and Ethical Concerns

The push for government endorsement of psychedelic therapies raises numerous ethical questions. Should substances with known psychoactive properties be part of mainstream health care? The regulatory environment surrounding these compounds is fraught with challenges, including ensuring quality control, standardizing dosages, and preventing misuse. With the legalization movements in various regions, the potential for recreational abuse expands, risking public health and safety.

Historical Context and Social Implications

Looking back, the late 1960s and early 1970s were marked by a psychedelic counterculture that resulted in societal turmoil and increased drug abuse. The legacy of this era still looms large; many young individuals romanticize psychedelic use without regarding the severe consequences that accompanied its earlier popularity, including addiction, mental health crises, and a societal disregard for safety protocols.

A Dangerous Precedent

By calling for a more prominent role for psychedelics in treatment protocols, the advocates of the ‘PsychedeliCare’ initiative may unintentionally set a dangerous precedent. Replacing established, evidence-based treatments with unproven psychedelic therapies could detract from the very real progress made in mental health care. It could shift focus away from holistic approaches that consider lifestyle, therapeutic counseling, and medication tailored to individual needs.

Conclusion

The debate surrounding the ‘PsychedeliCare’ initiative should prompt a vigilant and cautious examination of the implications of endorsing psychedelics as treatment options. While there is a critical need for innovative approaches in mental health care, rushing to embrace unproven therapies poses significant risks. It is paramount that we prioritize rigorous scientific scrutiny, ethical considerations, and the well-being of individuals over the allure of quick solutions. The only clear path forward is one grounded in proven therapies, comprehensive research, and unwavering commitment to public health.

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Why chocolate should not be given to dogs

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Chocolate is a favorite delicacy for people, but for cats and dogs it is a real poison, writes the magazine ” Sciences et Avenir” and explains why pets should not be “pampered” with chocolate under any circumstances.

For them, chocolate is toxic, because it is not properly absorbed by their body. This is due to the alkaloid theobromine, which is contained in cocoa and therefore in chocolate.

The substance becomes dangerous to health when large amounts of it are stored in the liver. About 12 grams of theobromine are contained in dark chocolate, twice as much in milk chocolate, and very small amounts in white chocolate.

Theobromine does not harm humans, as the human body manages to break it down quickly.

However, it takes 20 hours for dogs to get rid of this molecule. It can build up in their liver and cause poisoning if large amounts of chocolate are ingested at once.

Among the symptoms are vomiting, diarrhea, rapid pulse, convulsions.

The same is true for cats. However, they are less attracted to chocolate than dogs because they cannot taste sweets with their tongues, although there are exceptions.

In addition, pet obesity is the subject of a number of educational campaigns aimed at owners.

A court in North West England has banned a British man from keeping pets for the next 10 years because his Dalmatian became too fat. wrote the English tabloid “Sun” in November 2009.

40-year-old man John Green, a resident of Macclesfield in Cheshire, showed extreme irresponsibility towards his dog Barney and fed him chips and chocolate.

Thus, in just three months, it became several times fatter than normal for its breed and reached 70 kg.

Green was tipped off by alarmed, vigilant fellow citizens.

Animal control officials warned Green that his dog’s health was in danger and recommended that he be put on a diet.

However, he did not follow the recommendations and the dog continued to gain weight.

The Dalmatian was eventually removed from his owner’s home in June and put on a diet in a private kennel, where staff made sure he got enough exercise.

As a result, Barney, who is eight years old, lost 40 kg.

Green pleaded guilty to causing his dog unnecessary suffering, but the court found some mitigating circumstances because the man treated Barney more like a friend than a dog and did not realize he was harming him.

That’s why Green was only sentenced to 200 hours of community service and to pay £780 in costs.

Illustrative Photo by Glenn: https://www.pexels.com/photo/high-angle-photo-of-a-corgi-looking-upwards-2664417/

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Russian Orthodox Church calls on mass culture to abandon ‘images promoting alcoholism’

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On the occasion of the Day of Sobriety celebrated in the country today, the Russian Orthodox Church called on mass culture not to promote alcoholism, TASS reported.

The agency recalls that the All-Russian Day of Sobriety is celebrated on the initiative of the Russian Orthodox Church on September 11 to remind people of the harm caused by alcohol. On this day, in some parts of Russia, the sale of alcohol is limited or completely prohibited.

“The culture of attitude towards this is very important. There are many “nice jokes” about alcoholism in our everyday culture. There is nothing good about that. We know what the state of intoxication leads to. Those who deal with mass culture should make an effort that the image of the “dear drunkard” should still leave our mass culture,” said the head of the synodal department of the Moscow Patriarchate for Church Interaction on the sidelines of the St. Petersburg Forum of United Cultures with society and media Vladimir Legoida.

Asked whether it would be appropriate to ban or restrict the sale of alcohol across the country, he said “that would be wonderful”. “But it is important that people do this consciously, independently, not because someone is forcing them, and also that there is, as it is customary to say, a public consensus,” he stated.

Legoida noted that the category of “sobriety” is important for the church in general, which refers not only to abstinence from alcohol.

Meanwhile, during a press conference dedicated to the All-Russian Day of Sobriety, Russia’s Deputy Health Minister Oleg Salagai said that alcohol abuse can reduce a man’s life expectancy by six years and a woman by five years.

“The systemic measures that were adopted allowed us to really reduce alcohol consumption. Today, it can be confidently said that Russia is not one of the most drinking countries in the world,” said the deputy minister, who pointed out that in 2023 alcohol consumption in the country was about 8.4 liters per person, while at the beginning of the century the indicator was in double digits.

Illustrative Photo by EVG Kowalievska: https://www.pexels.com/photo/selective-focus-photography-of-assorted-brand-liquor-bottles-1128259/

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